Nexgard Chewables For Small Dogs – NEXGARD contains Afoxolaner, an acaricide for oral treatment and prevention of flea, tick and mite infestations in dogs and puppies 8 weeks of age and older, for one month after a single administration. Afoxolaner’s ingredients target and kill adult ticks before they lay eggs. NexGard is available in four sizes of beef flavored, soft chews for oral administration for dogs and puppies according to their weight.
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Nexgard Chewables For Small Dogs
Rx Nexgard, Dog 4 10lb, 6 Month
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Nexgard Chewable Tablets For Dogs 4 10 Lbs
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Home > Heartworm, Flea & Tick Protection > NexGard Flea & Tick Chewables for Dogs > NexGard Chewables for Dogs 4-10 lbs (1 Chew) Orange
Compounding is often thought of as the process of mixing or combining drugs to create a drug that is tailored to the needs of each patient.
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NexGard Flea & Tick Chewables for Dogs is a brand new, revolutionary flea and tick preventative from the makers of Frontline®, the #1 choice of veterinarians. It’s the first flea and tick repellent of its kind because it comes in a delicious beef flavor that helps protect your dog from flea and tick infestations for a full 30 days. That means no more worrying about dirty medication or accidentally washing it off your dog in the shower! It can also be administered along with your dog’s heart medication without interruption for your convenience.
NexGard keeps your pet safe from adult ticks by killing them before they have a chance to lay eggs, reducing the likelihood of a tick infestation. It also kills American ticks, reducing your pet’s risk of tick-borne diseases.
NexGard kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of the black legged tick (Ixodes scapularis), American dog tick (Dermacentor variabilis), Lone Star tick (Amblyomma americanum). , and brown dog tick (Rhipicephalus sanguineus) infestation in dogs and puppies 8 weeks old and older, weighing 4 pounds of body weight or more, for one month.
NexGard contains new ingredients that are not used to prevent fleas and other ticks. Afoxolaner, the ingredient in NexGard, is rapidly absorbed into your pet’s bloodstream, where a good concentration makes your pet’s blood toxic to insects without affecting your pet’s health. Afoxolaner is slowly metabolized to ensure that it remains in your pet’s bloodstream at the proper concentration for a full 30 days.
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When a flea or tick tries to feed on your pet’s blood, Afoxolaner acts on their central nervous system by inhibiting an important neurotransmitter that causes immediate death. This means your pet gets amazing protection in a tasty treat! NexGard is a prescription only drug, so talk to your veterinarian about using it on your pet.
NexGard can be taken with or without food. Care should be taken that the dog eats the complete dose, and the treated animal should be observed for several minutes to ensure that part of the dose is not lost or rejected. If it is suspected that one dose has been lost or if there is vomiting within 2 hours after taking, another dose is taken again. If a dose is missed, administer NexGard and request a monthly dosing schedule.
NexGard therapy can be started at any time of the year. In areas with year-round flies, monthly treatments with NexGard should continue throughout the year without interruption.
To reduce the possibility of reinfestation of fleas, it is important to treat all animals in the household with an approved flea control product.
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Not for human use. Keep this and all medicines out of the reach of children. In case of accidental ingestion, contact a doctor immediately.
The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures (see Adverse Effects).
In a well-controlled US field study that included a total of 333 families and 615 treated dogs (415 treated with Afoxolaner; 200 treated with active control), no serious adverse reactions were observed with NexGard.
1% within one of the three months of observation is presented in the following table. The most commonly reported adverse reaction is vomiting. The occurrence of nausea was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. Five treated dogs experienced anorexia during the study, and two of those dogs experienced vomiting with the first dose but not with subsequent doses.
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In a US field study, dogs with a history of seizures experienced seizures on the same day after the first injection and on the same day after the second dose of NexGard. This dog had a third seizure a week after the third dose. The dog remains registered and completes the study. Another dog had a history of seizures 19 days after the third dose of NexGard. The dog remains registered and completes the study. A third dog with a history of seizures received NexGard and was seizure-free during the study.
To report suspected side effects, for technical assistance or to receive assistance For a copy of the MSDS, contact Merial at 1-888-637-4251 or www.merial.com/nexgard. For more information on reporting adverse drug reactions for animals, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth.
Afoxolaner is a member of the isoxazoline family, shown to bind to the binding site to inhibit the insect and acarine ligand-gated chloride channels, especially the blockade by the neurotransmitter gamma-aminobutyric acid (GABA), thus pre- and post-synaptic inhibition. Transfer of chloride ions across the cell membrane. Afoxolaner-induced hyperexcitation for a long time leads to uncontrolled activity of the central nervous system and the death of insects and acarines. The selective toxicity of afoxolaner between insects and acarines and mammals can come from the different sensitivity of insects and acarine GABA receptors compared to GABA receptors of mammals.
99% efficiency after eight hours. In a separate well-controlled laboratory study, NexGard was 100% effective against adult ticks 24 hours after infection for 35 days, and 93% effective at 12 hours after infection through day 21, and on day 35. NexGard was 81.1% effective. 12 hours after infection. Dogs in the treated and control groups infected with fleas on day 1 produced flea eggs 12 and 24 hours after treatment (0-11 eggs and 1-17 eggs in NexGard-treated dogs, and 4-90 eggs in 0-118 eggs. in control dogs, at 12 and 24 hours respectively). At the next post-infection evaluation, fleas from dogs in the treated group failed to produce significant eggs (0-1 eggs), while fleas from dogs in the control group continued to produce eggs (1-141 eggs).
Nexgard® (afoxolaner) Chewables
In a 90-day US field study conducted in households with existing flea infestations of varying severity, the effectiveness of NexGard against fleas at day 30, 60 and 90 visits compared to baseline was 98.0%, 99.7% and 99.9%, respectively.
Data from three studies (two laboratory and one field) show that NexGard kills fleas before they lay eggs, thus preventing subsequent flea infestations after starting treatment for existing flea infestations.
As part of a safety study, NexGard was administered orally
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