Where To Buy Nexgard Chewables For Dogs – Home > Pet Prescription Medicine > NexGard Flea & Tick Dog Chews > NexGard Dog Chews 24.1-60 lbs (6 Chews) Purple
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Where To Buy Nexgard Chewables For Dogs
Home > Top Medications for Dogs > NexGard Flea & Tick Chews for Dogs > NexGard Chews for Dogs 24.1-60 lbs (6 Chews) Purple
Nexgard Chewables For Dogs 25
Home > Shop by Category > Heartworm, Flea & Tick Protection > NexGard Flea & Tick Chews for Dogs > NexGard Chews for Dogs 24.1-60 lbs (6 Chews) Purple
Home > Heartworm, Flea & Tick Protection > NexGard Flea & Tick Chews for Dogs > NexGard Chews for Dogs 24.1-60 lbs (6 Chews) Purple
Drug compounding is often thought of as the process of mixing or combining drugs to create a drug tailored to the needs of an individual patient.
NexGard Flea & Tick Chewables for Dogs is a brand new, revolutionary flea and tick preventative from the makers of Frontline®, the #1 choice of veterinarians. It is the first flea and tick killer of its kind as it comes in a delicious soft beef flavored chew that protects your dog from flea and tick infestation for up to 30 days. This means you no longer have to worry about messy threads or accidentally washing your dog during the bath! It can also be safely taken with your dog’s heartworm medication for your convenience.
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NexGard protects your pet from adult fleas by killing them before they have a chance to lay eggs, reducing the chance of flea infestation. It also kills the American dog tick, reducing the risk of fatal tick-borne disease in your pet.
NexGard kills adult fleas and is indicated for the treatment and prevention of flea (Ctenocephalides felis) infestations, and black-legged ticks (Ixodes scapularis), American dog ticks (Dermacentor variabilis), lone star ticks (Amblyomma americanum). ) for the treatment and control of , and the brown dog tick (Rhipicephalus sanguineus) in dogs and puppies 8 weeks of age and older, weighing 4 kilograms of body weight or more, for one month.
NexGard contains a brand new ingredient not used in any other flea and tick protection. Afoxolaner, the ingredient in NexGard, is rapidly absorbed into your pet’s blood, where a good concentration makes your pet’s blood toxic to insects without affecting your pet’s health. Afoxolaner is metabolized gradually to ensure that it remains in your pet’s blood at the correct concentration for a full 30 days.
When a flea or tick tries to feed on your pet’s blood, Afoxolaner works on their central nervous system by blocking an important neurotransmitter, causing immediate death. This means your pet has amazing protection in a tasty treat! NexGard is a prescription-only drug, so talk to your vet about using it for your pet.
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NexGard can be given with or without food. Care should be taken to ensure that the dog eats all of the food and the treated animal should be observed for several minutes to ensure that some of the food is not wasted or rejected. If a dose is suspected or if vomiting occurs within two hours of administration, repeat the dose with another full dose. If a dose is missed, administer NexGard and resume the monthly dosing schedule.
Treatment with NexGard can be started at any time of the year. In areas where fleas are common year-round, monthly NexGard treatments should be continued throughout the year without interruption.
To reduce the chance of reinfestation by fleas, it is important that all animals in the home are treated with an approved flea control product.
Not for human use. Keep this and all medicines out of the reach of children. In case of accidental ingestion, contact a doctor immediately.
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The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures (see Adverse Reactions).
In a well-controlled US field study involving a total of 333 families and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard.
1% within each of the three month observations is shown in the table below. The most frequently reported adverse reaction was vomiting. The occurrence of vomiting was generally self-limited and of short duration and decreased with subsequent dosing in both groups. Five dogs treated during the study experienced anorexia and two of these dogs experienced anorexia with the first dose but not subsequent doses.
In a US field study, a dog with a history of seizures developed seizures on the same day after receiving the first dose and on the same day after receiving the second dose of NexGard. The dog had a third attack a week after receiving the third dose. Dogs were enrolled and completed the study. Another dog with a history of seizures developed a seizure 19 days after the third dose of NexGard. Dogs were enrolled and completed the study. A third dog with a history of seizures received NexGard and had no seizures throughout the study.
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To report suspected adverse events, for technical assistance, or to obtain a copy of the MSDS, contact Merial at 1-888-637-4251 or www.merial.com/nexgard. For additional information about adverse drug experience reporting for animal medications, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth.
Afoxolaner is a member of the isoxazoline family, which has been shown to bind to the binding site to inhibit extrinsic ligand-gated chloride channels, specifically those blocked by the neurotransmitter gamma-aminobutyric acid (GABA). Thus, braking the front and rear. synaptic clefts. Prolonged hyperexcitation of chloride ions across cell membranes caused by afoxolaner results in uncontrolled central nervous system activity and death of insects and eccrines. The selective toxicity of afoxolaner between insects and acarines and mammals can be inferred from the differential sensitivity of insect and acarine GABA receptors versus mammalian GABA receptors.
99% effectiveness in eight hours. In a separate well-controlled laboratory study, NexGard demonstrated 100% effectiveness against adult fleas for 35 days and was 93% effective at 12 hours post-infestation for 21 days and 35 days. NexGard was 81.1% effective 12 hours after infection. Dogs in the treated and control groups that were infested with fleas on day 1 produced flea eggs at 12 and 24 hours after treatment (0-11 eggs and 1-17 eggs in Nexguard-treated dogs, and 4-90 eggs and 0 -118 eggs in control dogs, 12 and 24 hours, respectively). In the post-infection evaluation, dog fleas in the treated group were essentially unable to produce any eggs (0-1 eggs) while dog fleas in the control group continued to produce eggs (1-141 eggs).
In a 90-day US field study conducted in households with existing flea infestations of varying severity, the effectiveness of NexGard against fleas at 30, 60, and 90 visits compared to baseline was 98.0%, 99.7%, respectively and 99.9%.
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Overall, data from three studies (two laboratory and one field) show that NexGard kills fleas before they lay eggs, thereby preventing flea infestation after treatment for existing flea diseases is started.
In a marginal safety study, NexGard was administered orally to 8- to 9-week-old beagle puppies at 1, 3, and 5 times the maximum dose (6.3 mg/kg) for three treatments every 28 days. After three treatments were performed. every 14 days, for a total of six treatments. Dogs in the control group were sham operated. There were no clinically relevant treatment effects on physical examination, body weight, food consumption, clinical pathology (hematology, clinical chemistry, or coagulation tests), gross pathology, histopathology, or organ weight. Vomiting occurred throughout the study, with similar incidence in the treated and control groups, including one dog in the 5x group that vomited four hours after treatment.
In a well-controlled field study, NexGard was used with other medications, such as vaccines, anthelmintics, antibiotics (including topical), steroids, NSAIDs, anesthetics, and antihistamines. No adverse reactions have been observed with the simultaneous use of NexGard with other drugs.
If a dose is missed, administer the usual dose of NexGard Chewables and resume the monthly dosing schedule.
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NexGard Chewables require a prescription. Feed appropriately based on your dog’s weight. (See how to use it). If a dose is suspected or vomiting occurs within two hours of resuming with another full dose. NexGard Chewables can be taken with or without food. NexGard Chewables should be administered year-round. Treat all pets in your home to reduce the risk of flea infestation.
The most commonly reported adverse reactions include vomiting, dry/cracked skin, diarrhea, lethargy, and loss of appetite. The onset of vomiting was usually self-limiting and of short duration and subsided with subsequent feeding. There are no known contraindications to the use of NexGard Chewables.
The active ingredient in NexGard Chewables is Afoxolaner. NexGard Chewables kill adult fleas and are indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of the American dog tick.
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